Treatment

DIAGNOSIS: Schizophrenia

TREATMENT: Group Cognitive Remediation Therapy for Schizophrenia

BRIEF SUMMARY

  • Basic premise: "Cognitive functions such as executive function, learning & memory, processing speed, and sustained attention are frequently impaired and play an important role in the functional impairments seen in schizophrenia."
  • Essence of therapy: "Cognitive remediation (CR) or cognitive rehabilitation interventions are designed to improve cognitive function through repeated practice of cognitive tasks and / or strategy training. CR interventions are typically time-limited. They can be conducted individually or in groups. Some involve extensive use of computers while others focus primarily on paper-and-pencil tasks. Most CR interventions take into account the motivational and emotional deficits that are often present in schizophrenia as well. The goal of CR is to improve cognitive function. Research has shown small to medium effects of CR on neuropsychological measures of cognition, but whether these improvements are sustained or whether they translate into improved functioning remains unclear."

TREATMENT RESOURCES

TREATMENT MANUALS

Compensatory Cognitive Training (CogSMART)

Integriertes Psychologisches Therapieprogramm bei schizophren Erkrankten IPT (Roder, V., Brenner, H. D., & Kienzle, N.)

INT-Integrated neurocognitive therapy for schizophrenia patients (Roder, V., Müller, D. R.)

Voices group protocol (Wykes, T. Hayward, P., & P, A. -M.)

ADDITIONAL RESOURCES

CogSMART stands for: Cognitive Symptom Management and Rehabilitation Therapy (CogSMART)

SUPPORTING STUDIES

Burlingame, G. M., Svien, H, Hoppe, L., Hunt, I., & Rosendahl, J. (2020). Group therapy for schizophrenia: A meta-analysis. Psychotherapy, 57(2), 219-236. 

https://doi.org/10.1037/pst0000293

Farreny, A., Aguado, J., Ochoa, S., Huerta-Ramos, E., Marsà, F., López-Carrilero, R., Carral, V., Haro, J. M., & Usall, J. (2012). REPYFLEC cognitive remediation group training in schizophrenia: Looking for an integrative approach. Schizophrenia Research, 142(1-3), 137-144.

https://doi.org/10.1016/j.schres.2012.08.035

Katsumi, A., Hoshino, H., Fujimoto, S., Yabe, H., Ikebuchi, E., Nakagome, K., & Niwa, S. -I. (2019). Effects of cognitive remediation on cognitive and social functions in individual with schizophrenia. Neuropsychological Rehabilitation, 29(9), 1475-1487. 

https://doi.org/10.1080/09602011.2017.1409639

Keefe, R. S. E., Vinogradov, S., Medalia, A., Buckley, P. F., Caroff, S. N., D’Souza, D. C., Harvey, P. D., Graham, K. A., Hamer, R. M., Marder, S. M., Miller, D. D., Olson, S. J., Patel, J. K., Velligan, D., Walker, T. M., Haim, A. J., & Stroup, T. S. (2012). Feasibility and pilot efficacy results from the multisite cognitive remediation in the schizophrenia trials network (CRSTN) randomized controlled trial. The Journal of Clinical Psychiatry, 73(7), 1016-1022. 

https://doi.org/10.4088/JCP.11m07100

Kidd, S. A. Kaur, J., Virdee, G., George, T. P., McKenzie, K., & Herman, Y. (2014). Cognitive remediation for individuals with psychosis in a supported education setting: A randomized controlled trial. Schizophrenia Research, 157(1-3), 90-98. 

https://doi.org/10.1016/j.schres.2014.05.007

Lecardeur, L., Stip, E., Giguere, M., Blouin, G., Rodriguez, J. -P., & Champagne-Lavau, M. (2009). Effects of cognitive remediation therapies on psychotic symptoms and cognitive complaints in patients with schizophrenia and related disorders: A randomized study. Schizophrenia Research, 111(1-3), 153-158.

https://doi.org/10.1016/j.schres.2009.03.029

Matsuda, Y., Morimoto, T., Furukawa, S., Sato, S., Hatsuse, N., Iwata, K., Kimura, M., Kishimoto, T., & Ikebuchi, Em. (2018). Feasibility and effectiveness of a cognitive remediation programme with original computerised cognitive training and group intervention for schizophrenia: a multicentre randomised trial. Neuropsychological Rehabilitation, 28(3), 387-397.

https://doi.org/10.1080/09602011.2016.1181555

Mendella, P. D., Burton, C. Z., Tasca, G. A., Roy, P., St. Louis, L., & Twamley, E. W. (2015). Compensatory cognitive training for people with first-episode schizophrenia: Results from a pilot randomized controlled trial. Schizophrenia Research, 162(1-3), 108-111. 

https://doi.org/10.1016/j.schres.2015.01.016

Morimoto, T., Matsuda, Y., Matsuoka, K., Yasuno, F., Ikebuchi, E., Kameda, H., Taoka, T., Miyasaka, T., Kichikawa, K., & Kishimoto, T. (2018). Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial. BMC Psychiatry, 18(83).

https://doi.org/10.1186/s12888-018-1667-1

Mueller, D. R., Schmidt, S. J., & Roder, V. (2015). One-year randomized controlled trial and follow-up of integrated neurocognitive therapy for schizophrenia outpatients. Schizophrenia Bulletin, 41(3), 604-616. 

https://doi.org/10.1093/schbul/sbu223

Mueller, D. R., Khalesi, Z., Benzing, V., Castiglione, C. I., & Roder, V. (2017). Does Integrated Neurocognitive Therapy (INT) reduce severe negative symptoms in schizophrenia outpatients? Schizophrenia Research, 188, 92-97. 

https://doi.org/10.1016/j.schres.2017.01.037

Rakitzi, S., Georgila, P., Efthimiou, K., & Mueller, D. R. (2016). Efficacy and feasibility of the Integrated Psychological Therapy for outpatients with schizophrenia in Greece: Final results of a RCT. Psychiatry Research, 242, 137-143. 

https://doi.org/10.1016/j.psychres.2016.05.039

Sánchez, P., Peña, J., Bengoetxea, E., Ojeda, N., Elizagárate, E., Ezcurra, J., & Gutiêrrez, M. (2014). Improvement in negative symptoms and functional outcome after a new generation cognitive remediation program: A randomized controlled trial. Schizophrenia Bulletin, 40(3), 707-715. 

https://doi.org/10.1093/schbul/sbt057

Tan, S., Zou, Y., Wykes, T., Reeder, C., Zhu, X., Yang, F., Zhao, Y., Tan, Y., Fan, F., & Zhou, D. (2016). Group cognitive remediation therapy for chronic schizophrenia: A randomized controlled trial. Neuroscience Letters, 626, 106-111. 

https://doi.org/10.1016/j.neulet.2015.08.036

Twamley, E. W., Vella, L., Burton, C. Z., Heaton, R. K., &  Jeste, D. V. (2012). Compensatory cognitive training for psychosis: Effects in a randomized controlled trial. The Journal of Clinical Psychiatry, 73(9), 1212-1219. 

https://doi.org/10.4088/JCP.12m07686

Vauth, R., Corrigan, P. W., Clauss, M., Dietl, M., Dreher-Rudolph, M., Stieglitz, R. -D., & Vater, R. (2005). Cognitive strategies versus self-management skills as adjunct to vocational rehabilitation. Schizophrenia Bulletin, 31(1), 55-66, 

https://doi.org/10.1093/schbul/sbi013

Wölwer, W., Frommann, N., Halfmann, S., Piaszek, A., Streit, M., & Gaebel, W. Remediation of impairments in facial affect recognition in schizophrenia: Efficacy and specificity of a new training program. Schizophrenia Research, 80(2-3), 295-303. 

https://doi.org/10.1016/j.schres.2005.07.018